Wei Yang Selected Research

Protein Kinases (Protein Kinase)

10/2022	Discovery of 3,4-Dihydrobenzo[f][1,4]oxazepin-5(2H)-one Derivatives as a New Class of Selective TNIK Inhibitors and Evaluation of Their Anti-Colorectal Cancer Effects.
1/2022	Receptor-interacting protein kinase 2 (RIPK2) stabilizes c-Myc and is a therapeutic target in prostate cancer metastasis.
1/2021	Quyu Shengxin Decoction Alleviates DSS-Induced Ulcerative Colitis in Mice by Suppressing RIP1/RIP3/NLRP3 Signalling.
1/2020	PERK (Protein Kinase RNA-Like ER Kinase) Branch of the Unfolded Protein Response Confers Neuroprotection in Ischemic Stroke by Suppressing Protein Synthesis.
1/2020	Protein kinase 2 (CK2) controls CD4+ T cell effector function in the pathogenesis of colitis.
3/2019	Correction to Identification of 5-(2,3-Dihydro-1 H-indol-5-yl)-7 H-pyrrolo[2,3- d]pyrimidin-4-amine Derivatives as a New Class of Receptor-Interacting Protein Kinase 1 (RIPK1) Inhibitors, Which Showed Potent Activity in a Tumor Metastasis Model.
12/2018	Identification of 5-(2,3-Dihydro-1 H-indol-5-yl)-7 H-pyrrolo[2,3- d]pyrimidin-4-amine Derivatives as a New Class of Receptor-Interacting Protein Kinase 1 (RIPK1) Inhibitors, Which Showed Potent Activity in a Tumor Metastasis Model.
8/2018	Dihydromyricetin Inhibits Lead-Induced Cognitive Impairments and Inflammation by the Adenosine 5'-Monophosphate-Activated Protein Kinase Pathway in Mice.
11/2015	Long-term safety and efficacy of imatinib in pulmonary arterial hypertension.
2/2013	Hepatitis C virus inhibits AKT-tuberous sclerosis complex (TSC), the mechanistic target of rapamycin (MTOR) pathway, through endoplasmic reticulum stress to induce autophagy.

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Wei Yang Research Topics

Disease

423	Neoplasms (Cancer) 05/2024 - 05/2003
107	Hepatocellular Carcinoma (Hepatoma) 03/2024 - 07/2005
105	Inflammation (Inflammations) 06/2024 - 02/2006
85	Infections 04/2024 - 02/2002
73	Neoplasm Metastasis (Metastasis) 01/2024 - 05/2003
63	Breast Neoplasms (Breast Cancer) 05/2024 - 09/2006
35	Glioma (Gliomas) 04/2024 - 01/2014
35	Stomach Neoplasms (Stomach Cancer) 01/2024 - 02/2011
33	Cardiovascular Diseases (Cardiovascular Disease) 01/2024 - 11/2006
30	Carcinogenesis 01/2023 - 02/2006
30	Hypertension (High Blood Pressure) 01/2023 - 05/2007
29	COVID-19 04/2024 - 01/2020
29	Myocardial Infarction 01/2024 - 11/2006
29	Stroke (Strokes) 05/2023 - 12/2006
28	Hypoxia (Hypoxemia) 03/2023 - 02/2008
28	Chronic Renal Insufficiency 01/2023 - 06/2011
27	Colorectal Neoplasms (Colorectal Cancer) 12/2023 - 08/2015
26	Ischemia 02/2024 - 02/2008
25	Prostatic Neoplasms (Prostate Cancer) 10/2023 - 07/2009
24	Lung Neoplasms (Lung Cancer) 04/2024 - 01/2011
24	Carcinoma (Carcinomatosis) 01/2023 - 04/2004
23	Glioblastoma (Glioblastoma Multiforme) 04/2024 - 01/2013
23	Type 2 Diabetes Mellitus (MODY) 12/2023 - 08/2010
22	Wounds and Injuries (Trauma) 04/2024 - 12/2008
22	Alzheimer Disease (Alzheimer's Disease) 04/2024 - 10/2010
22	Fibrosis (Cirrhosis) 11/2023 - 12/2005
22	Pain (Aches) 01/2023 - 04/2010
21	Atherosclerosis 10/2023 - 06/2012
21	Hemorrhage 08/2023 - 11/2003
21	Insulin Resistance 01/2023 - 11/2008
20	Heart Failure 05/2022 - 04/2006
17	Obesity 01/2024 - 05/2007
17	Hypersensitivity (Allergy) 01/2024 - 04/2009
17	Leukemia 01/2023 - 05/2005
16	Disease Progression 05/2024 - 04/2015
16	Neural Tube Defects (Exencephaly) 03/2024 - 11/2003
16	Cognitive Dysfunction 02/2024 - 10/2016
16	Neuroinflammatory Diseases 02/2024 - 01/2018
16	Mitochondrial Diseases (Mitochondrial Disease) 01/2024 - 03/2014
16	Ischemic Stroke 01/2023 - 01/2014
16	Chronic Kidney Failure (Chronic Renal Failure) 01/2020 - 12/2007
15	Adenocarcinoma 03/2024 - 11/2009
15	Coronary Disease (Coronary Heart Disease) 01/2021 - 11/2006
15	Spinal Dysraphism (Spina Bifida) 01/2018 - 06/2005
14	Body Weight (Weight, Body) 04/2024 - 05/2013
14	Thrombosis (Thrombus) 03/2024 - 08/2007
14	Liver Neoplasms (Liver Cancer) 03/2024 - 02/2005
14	Necrosis 01/2024 - 11/2003
14	Congenital Abnormalities (Deformity) 01/2022 - 06/2005
13	Multiple Myeloma 05/2024 - 10/2011
13	Uterine Cervical Neoplasms (Cancer of the Cervix) 04/2024 - 01/2017
12	Colitis 02/2024 - 01/2014
12	Sepsis (Septicemia) 01/2024 - 10/2017
12	Reperfusion Injury 01/2024 - 02/2011

Drug/Important Bio-Agent (IBA)

190	Proteins (Proteins, Gene)FDA Link 04/2024 - 06/2003
90	Biomarkers (Surrogate Marker)IBA 05/2024 - 08/2010
51	Long Noncoding RNAIBA 11/2023 - 07/2015
48	CytokinesIBA 11/2023 - 11/2003
45	Glucose (Dextrose)FDA LinkGeneric 10/2023 - 08/2010
44	MicroRNAs (MicroRNA)IBA 01/2023 - 04/2009
35	LipidsIBA 04/2024 - 11/2008
34	Messenger RNA (mRNA)IBA 05/2024 - 03/2010
31	Therapeutic UsesIBA 04/2024 - 02/2006
30	RNA (Ribonucleic Acid)IBA 04/2024 - 11/2017
29	AntigensIBA 01/2024 - 01/2010
24	Oxygen (Dioxygen)IBA 02/2024 - 04/2008
24	DNA (Deoxyribonucleic Acid)IBA 01/2023 - 12/2006
23	Peptides (Polypeptides)IBA 05/2023 - 02/2006
23	Small Interfering RNA (siRNA)IBA 12/2022 - 06/2010
22	Folic Acid (Vitamin M)FDA LinkGeneric 12/2022 - 07/2004
21	CateninsIBA 10/2023 - 06/2011
20	VaccinesIBA 05/2024 - 02/2008
20	Interleukin-6 (Interleukin 6)IBA 12/2023 - 11/2003
19	CalciumIBA 02/2024 - 09/2010
18	EnzymesIBA 02/2024 - 02/2008
17	Transcription Factors (Transcription Factor)IBA 10/2023 - 02/2008
17	InterferonsIBA 01/2023 - 02/2005
16	Indicators and Reagents (Reagents)IBA 04/2024 - 09/2007
16	LigandsIBA 01/2024 - 02/2002
16	AcidsIBA 10/2023 - 07/2012
16	Phosphotransferases (Kinase)IBA 05/2023 - 03/2012
15	Reactive Oxygen Species (Oxygen Radicals)IBA 03/2024 - 09/2010
15	CollagenIBA 01/2024 - 12/2008
15	Antiviral Agents (Antivirals)IBA 01/2024 - 03/2010
15	CreatinineIBA 04/2022 - 04/2013
14	AntioxidantsIBA 03/2024 - 01/2014
14	InterleukinsIBA 11/2023 - 07/2009
14	Cisplatin (Platino)FDA LinkGeneric 10/2023 - 06/2014
14	Insulin (Novolin)FDA Link 01/2023 - 01/2009
13	UbiquitinIBA 10/2022 - 05/2008
13	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 03/2022 - 07/2003

Therapy/Procedure

216	Therapeutics 05/2024 - 02/2004
95	Drug Therapy (Chemotherapy) 03/2024 - 09/2006
66	Radiofrequency Ablation 02/2024 - 02/2004
54	Radiotherapy 02/2024 - 02/2005
52	Immunotherapy 05/2024 - 02/2008
30	Chinese Traditional Medicine (Traditional Chinese Medicine) 04/2024 - 05/2005
26	Neoadjuvant Therapy 05/2024 - 05/2011
16	Aftercare (After-Treatment) 08/2022 - 07/2005
13	Transplantation 10/2023 - 06/2005